Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo.

Authors :: Sullivan, Matthew P.
Adams, Muneebah
Riisom, Mie
Herbert, Caitlin D.
Tong, Kelvin K. H.
Astin, Jonathan W.
Jamieson, Stephen M. F.
Hanif, Muhammad
Goldstone, David C.
Hartinger, Christian G.
Source :: Dalton Transactions: An International Journal of Inorganic Chemistry; 2/7/2023, Vol. 52 Issue 5, p1388-1392, 5p
Publication Year :: 2023
Abstract: Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cisplatin. DNA interaction studies support a mode of action related to intercalation. [ABSTRACT FROM AUTHOR]

Subjects :: PLATINUM
CANCER cells
CARBENE synthesis
DNA
BRACHYDANIO
CISPLATIN

Language :: English
ISSN :: 14779226
Volume :: 52
Issue :: 5
Database :: Complementary Index
Journal :: Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :: Academic Journal
Accession number :: 161599407
Full Text :: https://doi.org/10.1039/d2dt02539f

Full Text Access

Tools