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Safety of mRNA COVID-19 Vaccines in Patients with Inborn Errors of Immunity: an Italian Multicentric Study.

Authors :
Milito, Cinzia
Cinetto, Francesco
Garzi, Giulia
Palladino, Andrea
Puca, Marco
Brambilla, Elena
De Vitis, Camilla
Costanzo, Giulia
Scarpa, Riccardo
Punziano, Alessandra
Lagnese, Gianluca
Del Giacco, Stefano
Spadaro, Giuseppe
Quinti, Isabella
Firinu, Davide
Source :
Journal of Clinical Immunology; Feb2023, Vol. 43 Issue 2, p299-307, 9p
Publication Year :
2023

Abstract

Purpose: Little is known about vaccine safety in inborn errors of immunity (IEI) patients during the current vaccination campaign for COVID-19. To better investigate the reactogenicity and adverse event profile after two, three, and four doses of mRNA vaccines, we conducted an observational, multicentric study on 342 PID patients from four Italian Referral Centres. Methods: We conducted a survey on self-reported adverse reactions in IEI patients who received mRNA vaccine by administering a questionnaire after each dose. Results: Over the whole study period, none of the patients needed hospitalization or had hypersensitivity reactions, including anaphylaxis and delayed injection site reaction. After two vaccination doses, 35.4% of patients showed only local reactogenicity-related symptoms (RrS), 44.4% reported both systemic and local RrS, and 5% reported only systemic RrS. In more than 60% of cases, local or systemic RrS were mild. After the first and second booster doses, patients showed fewer adverse events (AEs) than after the first vaccination course. Patients aged 50 years and older reported adverse events and RrS less frequently. Among AEs requiring treatment, one common variable immune deficiency patient affected by T cell large granular lymphocytic leukemia developed neutropenia and one patient had Bell's paralysis perhaps during herpes zoster reactivation. Conclusion: Although our follow-up period is relatively short, the safety data we reported are reassuring. This data would help to contrast the vaccine hesitancy often manifested by patients with IEI and to better inform their healthcare providers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02719142
Volume :
43
Issue :
2
Database :
Complementary Index
Journal :
Journal of Clinical Immunology
Publication Type :
Academic Journal
Accession number :
161654816
Full Text :
https://doi.org/10.1007/s10875-022-01402-6