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Factors for poor oral health in long-term childhood cancer survivors.
- Source :
- BMC Oral Health; 2/4/2023, p1-11, 11p
- Publication Year :
- 2023
-
Abstract
- Background: Survivors of childhood cancer are at risk for therapy-related dental diseases. The purpose of the study was to investigate the associations between clinical, socioeconomic, and demographic factors and oral diseases in the St. Jude Lifetime Cohort (SJLIFE) participants. Methods: We performed a retrospective medical chart review and evaluated longitudinal self-reported dental outcomes in 4856 childhood cancer survivors and 591 community controls participating in the St. Jude Lifetime Cohort (SJLIFE) study. Univariate and multivariable logistic regression models were used to assess the impact of socioeconomic factors, treatment exposures and patient demographics on dental outcomes. Results: Cancer survivors were more likely to report microdontia (odds ratio (OR) = 7.89, 95% confidence interval (CI) [4.64, 14.90]), abnormal root development (OR = 6.19, CI [3.38, 13.00]), hypodontia (OR = 2.75, CI [1.83, 4.33]), enamel hypoplasia (OR = 4.24, CI [2.9, 6.49]), xerostomia (OR = 7.72, CI [3.27, 25.10]), severe gingivitis (OR = 2.04, CI [1.43, 3.03]), and ≥ 6 missing teeth (OR = 3.73, CI [2.46, 6.00]) compared to controls without cancer history. Survivors who received classic alkylating agents (OR = 1.6, CI [1.36, 1.88]), anthracycline antibiotics (OR = 1.22, CI [1.04, 1.42] or radiation therapy potentially exposing the oral cavity (OR = 1.48, CI [1.26, 1.72]) were more likely to report at least one dental health problem after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access to dental services. Survivors who had radiation therapy potentially exposing the oral cavity (OR = 1.52, CI [1.25, 1.84]) were also more likely to report at least one soft tissue abnormality after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access and utilization of dental services. Conclusions: Childhood cancer survivors have a higher prevalence of oral-dental abnormalities than the controls without a cancer history. Cancer treatment, socioeconomic factors, and access to oral health care contribute to the prevalence of dental abnormalities. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
TEETH
CONFIDENCE intervals
GINGIVITIS
ANTHRACYCLINES
HEALTH services accessibility
RADIATION-induced abnormalities
ORAL health
SELF-evaluation
MULTIPLE regression analysis
ORAL diseases
RETROSPECTIVE studies
ACQUISITION of data
HYPODONTIA
TUMORS in children
CANCER patients
SOCIOECONOMIC factors
RISK assessment
COMPARATIVE studies
CHILDREN'S dental care
MEDICAL records
DESCRIPTIVE statistics
TEETH abnormalities
XEROSTOMIA
ALKYLATING agents
RESEARCH funding
SOCIODEMOGRAPHIC factors
ODDS ratio
RADIOTHERAPY
DENTAL caries
LONGITUDINAL method
MOUTH
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14726831
- Database :
- Complementary Index
- Journal :
- BMC Oral Health
- Publication Type :
- Academic Journal
- Accession number :
- 161691968
- Full Text :
- https://doi.org/10.1186/s12903-023-02762-0