Current Trends in Host Cell Protein Detection for Biologics Manufacturing.

The article discusses the challenges associated with the common host cell protein (HCP) detection processes for protein drugs and presents suggestions to deal with them. It describes the difficulties in assessing HCP antibodies while using enzyme-linked immunosorbent assay (ELISA) method for HCP detection. It refers to enzyme conjugated HCP antibodies, HCP standards, and anti-HCP antibodies as three key reagents needed to develop HCP detection methods.