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Identification of two suppressor factors induced by early pregnancy factor.
- Source :
- Clinical & Experimental Immunology; Aug1988, Vol. 73 Issue 2, p219-225, 7p
- Publication Year :
- 1988
-
Abstract
- The binding of EPF to lymphocytes stimulates the release of soluble mediators, active in T cell dependent reactions, namely the rosette inhibition test and the adoptive transfer of contact sensitivity. On the basis of their ability to inhibit the delayed type hypersensitivity reaction in this latter assay, they have been classified as suppressor factors. This paper describes the identification of two EPF-induced suppressor factors. Unlike EPF which is neither species-restricted nor strain-restricted, these factors are genetically restricted in their action in the rosette inhibition test EPF-S<subscript>1</subscript> (estimated M<subscript>r</subscript> 14,000) is restricted to the I region of the mouse MHC, while EPF-S<subscript>2</subscript> (estimated M<subscript>r</subscript> 55,000) is restricted to a locus (or loci) outside the MHC. Like other antigen non-specific factors, release of these suppressor factors can be stimulated also by Con A. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
T cells
ALLERGIES
PREGNANCY
CONTACT dermatitis
ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 73
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16176326