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Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities.
- Source :
- Natural Product Research; Feb2023, Vol. 37 Issue 4, p571-578, 8p
- Publication Year :
- 2023
-
Abstract
- Five new glycosylated phenolic derivatives, rotundosides A-E (1-5), and three known glycosides (6-8) were isolated from the 95% alcohol extract of the bark of Ilex rotunda. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature data. All new compounds possessed a [5-O-(E)-caffeoyl]-β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl group. The anti-inflammatory properties of all isolated compounds were evaluated using a modified nitric oxide (NO) production in lipopolysaccharide (LPS)-induced leukemia cells in mouse macrophage (RAW264.7) method. Compound 8, dracunculifoside H, showed significant anti-inflammatory activity in vitro. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTI-inflammatory agents
GLYCOSIDES
NITRIC oxide
LIPOPOLYSACCHARIDES
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 37
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 161787220
- Full Text :
- https://doi.org/10.1080/14786419.2022.2078323