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A20 as a Potential New Tool in Predicting Recurrence and Patient's Survival in Oral Squamous Cell Carcinoma.
- Source :
- Cancers; Feb2023, Vol. 15 Issue 3, p675, 12p
- Publication Year :
- 2023
-
Abstract
- Simple Summary: Here, we examined the presence and clinical relevance of A20 in oral squamous cell carcinoma (OSCC). Using a tissue microarray (TMA), immunohistochemical A20 expression as well as tumor-infiltrating lymphocytes (TIL) were analyzed. Hereby, A20 expression was significantly increased in TILs and patients with elevated A20 expression in stromal CD3+ cells showed ameliorated survival in uni- as well as multivariable analyses. A20, known as a potent inhibitor of NF-κB signaling, has been characterized in numerous clinical as well as preclinical studies. Recently, especially in various malignant diseases, the prognostic and therapeutic relevance of A20 was investigated. In oral squamous cell carcinoma (OSCC) however, the characterization of A20 is uncharted territory. We analyzed a tissue microarray (TMA) of 229 surgically-treated OSCC patients (2003–2013). Immunohistochemical (IHC) stainings were performed for A20 and CD3; additionally, standard haematoxylin-eosin staining was applied. IHC findings were correlated with a comprehensive dataset, comprising clinical and pathohistological information. A20 expression was analyzed in tumor cells as well as in tumor infiltrating lymphocytes (TILs) and correlated with the overall survival (OS) and recurrence-free survival (RFS) using uni- and multivariable Cox regression. The median follow-up time was 10.9 years and the A20 expression was significantly decreased in CD3+ TILs compared to mucosa-infiltrating lymphocytes (MILs). In the Kaplan–Meier analyses, higher A20 expression in TILs was correlated with better OS (p = 0.017) and RFS (p = 0.020). In the multivariable survival analysis, A20 overexpression correlated with improved OS (HR: 0.582; 95% CI 0.388–0.873, p = 0.009) and RFS (HR 0.605; 95% CI 0.411–0.889, p = 0.011). Our results indicate a novel prognostic role for A20 in OSCC. Due to its elevated expression in TILs, further research is highly desirable, which therefore could offer new therapeutic opportunities for patients suffering from OSCC. [ABSTRACT FROM AUTHOR]
- Subjects :
- TISSUE arrays
STATISTICS
MOUTH tumors
STAINS & staining (Microscopy)
CONFIDENCE intervals
ACADEMIC medical centers
IMMUNOHISTOCHEMISTRY
MULTIVARIATE analysis
CANCER relapse
NF-kappa B
SURGERY
PATIENTS
RISK assessment
GENE expression
CANCER patients
TREATMENT effectiveness
DNA-binding proteins
RESEARCH funding
DESCRIPTIVE statistics
TUMOR markers
T cells
CELL lines
SQUAMOUS cell carcinoma
ANTIGENS
OVERALL survival
PROPORTIONAL hazards models
LONGITUDINAL method
CHEMICAL inhibitors
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 15
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 161822447
- Full Text :
- https://doi.org/10.3390/cancers15030675