Back to Search
Start Over
Exploring the Biological Properties of Zn(II) Bis thiosemicarbazone Helicates.
- Source :
- International Journal of Molecular Sciences; Feb2023, Vol. 24 Issue 3, p2246, 16p
- Publication Year :
- 2023
-
Abstract
- The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bisthiosemicarbazone ligands with different terminal groups, Zn<subscript>2</subscript>(L<superscript>Me</superscript>)<subscript>2</subscript>∙2H<subscript>2</subscript>O 1, Zn<subscript>2</subscript>(L<superscript>Ph</superscript>)<subscript>2</subscript>∙2H<subscript>2</subscript>O 2 and Zn<subscript>2</subscript>(L<superscript>PhNO2</superscript>)<subscript>2</subscript>3, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demonstrating in all cases low toxicity and an absence of covalent interaction with the proteins and oligonucleotides. The in vitro cytotoxicity of the helicates was tested against MCF-7 (human breast carcinoma), A2780 (human ovarian carcinoma cells), NCI-H460 (human lung carcinoma cells) and MRC-5 (normal human lung fibroblasts), comparing the IC<subscript>50</subscript> values with cisplatin. We will try to demonstrate if the terminal substituent of the ligand precursor exerts any effect in toxicity or in the antitumor activity of the zinc helicates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 24
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 161860512
- Full Text :
- https://doi.org/10.3390/ijms24032246