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Mechanisms of immune evasion of monkeypox virus.
- Source :
- Frontiers in Microbiology; 2/1/2023, Vol. 14, p1-4, 4p
- Publication Year :
- 2023
-
Abstract
- The mpox (disease caused by the monkeypox virus) epidemic in 2022 provides a good opportunity to study the immune response to mpox. Vaccinia virus-infected monocytes could be recognized by monkeypox virus-specific CD4+ and CD8+ T cells, which produce inflammatory cytokines including IFN? and TNFa. However, these cells are mostly unable to react to monkeypox virus-infected cells. The monkeypox virus also has no effect on the expression of MHC classes. Cells infected with monkeypox virus can prevent T cells from being activated via their T cell receptors. Insensitivity is an MHC-independent strategy for controlling antiviral T cells activation and inflammatory cytokines production. It is likely a critical aspect of virus spread in the infected host. The ability of monkeypox virus to spread efficiently as cell-associated viremia may be explained by the evasion strategies employed by the virus to subvert immunological surveillance by virus-specific T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- MONKEYPOX
T cell receptors
VIRAL transmission
T cells
PLANT viruses
VIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 1664302X
- Volume :
- 14
- Database :
- Complementary Index
- Journal :
- Frontiers in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 161953235
- Full Text :
- https://doi.org/10.3389/fmicb.2023.1106247