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Anti-inflammatory flavonoid derivatives from the heartwood of Dalbergia odorifera T. Chen.
- Source :
- Natural Product Research; Mar2023, Vol. 37 Issue 6, p928-935, 8p
- Publication Year :
- 2023
-
Abstract
- Two pairs of flavonoid enantiomers (1a/1b and 2a/2b) together with three known analogues (3–5) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2H)-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3‒5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC<subscript>50</subscript> values of 14.7 ± 0.3 μM, 40.2 ± 1.1 μM, and 3.2 ± 0.1 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLAVONOIDS
HEARTWOOD
ENANTIOMERS
NITRIC oxide
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 37
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 161970216
- Full Text :
- https://doi.org/10.1080/14786419.2022.2098494