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Efficacy and Clinical Significance of the Zuogui Pill on Premature Ovarian Failure via the GDF-9/Smad2 Pathway.
- Source :
- Nutrition & Cancer; 2023, Vol. 75 Issue 2, p488-497, 10p, 6 Charts, 1 Graph
- Publication Year :
- 2023
-
Abstract
- Our study aims to investigate the efficacy and clinical significance of the Zuogui pill (ZGP) on premature ovarian failure (POF) via the GDF-9/Smad2 pathway. Changes in clinical symptoms in the control group (treated with Femoston alone) and the treatment group (treated with ZGP combined with Femoston) were assessed before and after treatment. Sex hormone levels, serum inflammatory cytokine levels, and ultrasound parameters were measured before and after treatment. POF rat models were established using cyclophosphamide and the POF rats were treated with Femoston, or ZGP combined with Femoston. GDF-9 and Smad2 expression levels were determined by RT-qPCR. The follicle-stimulating hormone (FSH), luteinizing hormone (LH), interleukin (IL)-6, and IL-21 levels, and the pulsatility index (PI) and resistance index (RI) values were decreased, while the estradiol (E2) and anti-Mullerian hormone (AMH) levels, antral follicle count (AFC), ovarian volume (OV), mean ovarian diameter (MOD), and peak systolic velocity (PSV) values were increased in the treatment group compared to the control group. After treatment with ZGP combined with Femoston, GDF-9 and Smad2 expression in the ovarian tissues of POF rats increased. ZGP has a therapeutic effect on POF via modulation of the GDF-9/Smad2 pathway. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of plant extracts
DRUG efficacy
CYTOKINES
REVERSE transcriptase polymerase chain reaction
INTERLEUKINS
HERBAL medicine
ULTRASONIC imaging
HORMONE therapy
COMBINATION drug therapy
FOLLICLE-stimulating hormone
CELLULAR signal transduction
OVARIAN diseases
SEX hormones
CYCLOPHOSPHAMIDE
LUTEINIZING hormone
DESCRIPTIVE statistics
DATA analysis software
CHINESE medicine
GROWTH differentiation factors
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 75
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 162055461
- Full Text :
- https://doi.org/10.1080/01635581.2022.2123531