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AutophagosOMES: identification of autophagosomal cargo in CD4+ T cells by proteomics.
- Source :
- Autophagy; Mar2023, Vol. 19 Issue 3, p745-746, 2p
- Publication Year :
- 2023
-
Abstract
- Macroautophagy/autophagy, a cellular process that sequesters and breaks down cellular components in the lysosome/vacuole, is important in various events where cell composition undergoes changes. Broadly, autophagy is involved in T cell regulation including maintaining cell homeostasis. One process where a cell alters its composition is in the activation of helper T cells in the immune system. When helper (CD4<superscript>+</superscript>) T cells are activated by antigens, they both grow and alter their cellular components to become effector T cells. Autophagy is the process that facilitates the breakdown of these cellular components and is therefore hypothesized to have a role in CD4<superscript>+</superscript> T cell activation. Previous research has concluded that CD4<superscript>+</superscript> T cell activation induces autophagy, providing an avenue for further research aimed at examining the ways in which this induced autophagy affects CD4<superscript>+</superscript> T cell proliferation and function. Toward this end, Zhou et al. researched the autophagosomal cargo present within CD4<superscript>+</superscript> T cells and the impact this cargo has on CD4<superscript>+</superscript> T cell proliferation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15548627
- Volume :
- 19
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Autophagy
- Publication Type :
- Academic Journal
- Accession number :
- 162081107
- Full Text :
- https://doi.org/10.1080/15548627.2022.2161154