Persistent splenomegaly due to littoral cell angiomatosis in venetoclax-induced undetectable minimal residual disease of chronic lymphocytic leukemia.

A 76-year-old patient with a longstanding history of CLL presented with persistent massive splenomegaly and uMRD after venetoclax-based treatment. Persistent splenomegaly after treatment is a common finding in chronic lymphocytic leukemia (CLL). While uMRD is desirable in all CLL patients (especially for time-limited treatment schemes), the persistence of splenomegaly should prompt searching for additional conditions, whose treatment may be independent of CLL therapies. [Extracted from the article]