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PKCα interacts with Cav1.3 calcium channels to promote the Cav1.2/Cav1.3 duo tuning Th2 functions.
- Source :
- Allergy; Mar2023, Vol. 78 Issue 3, p879-882, 4p
- Publication Year :
- 2023
-
Abstract
- PKC interacts with Ca<subscript>v</subscript>1.3 calcium channels to promote the Ca<subscript>v</subscript>1.2/Ca<subscript>v</subscript>1.3 duo tuning Th2 functions In conclusion, the interaction of PKC with Ca SB v sb 1.3 upon TCR engagement is a new mechanism setting off calcium influx through Ca SB v sb 1 channels in non-excitable cells. Antisense oligonucleotides (ODN) targeting PKC mRNA (AS-PKC ) significantly decreased PKC but not PKC protein levels in Th2 cells (Figure 2A). [Extracted from the article]
- Subjects :
- CALCIUM channels
TH2 cells
PROTEIN kinase C
BRONCHIAL spasm
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 78
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 162242619
- Full Text :
- https://doi.org/10.1111/all.15611