Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients".

We appreciate the interest in our work from Kratz and Evans, questioning the role of I CHEK2 i germline variants in the development of childhood cancer, while their contribution to gender-specific tumors in adults is well established. CHEK2 germline variants in cancer predisposition: stalemate rather than checkmate. [Extracted from the article]