Influence of contrast media on long-term renal function and outcomes in patients with septic acute kidney injury.

배경: Computed tomography (CT) is a very useful tool for evaluating the etiology of patients with sepsis or septic shock. However, it is difficult to obtain contrast-enhanced CT images due to concerns about nephrotoxicity caused by contrast media, especially in patients with septic acute kidney injury (AKI). In this study, we aim to investigate the relationship between contrast media administration and long-term mortality and chronic kidney disease in patients with septic AKI. 방법: A total of 1,521 patients with septic shock admitted to a tertiary hospital in South Korea from July 2008 to November 2019 were retrospectively reviewed. A total of 609 adult septic shock patients with AKI who underwent contrast or non-contrast CT scans were enrolled. The primary outcome was 90-day mortality rate. The secondary outcomes were worsening AKI, 28-day mortality rate, chronic kidney disease, and maintain dialysis at 90 days between contrast CT group and non-contrast CT group. 결과: Of 609 septic AKI patients, 220 patients (36.1%) underwent contrast CT and 389 patients (63.9%) underwent non-contrast CT. The median age was 70.9 years, and 305 (50.1%) were male. There were no statistically significant differences in the outcomes between the contrast and non-contrast CT groups: 90-day mortality, 55.3% vs. 57.4%, p=0.682; worsening AKI, 1.8% vs. 2.1%, p=0.999; 28-day mortality, 41.4% vs. 42.3%, p=0.898; chronic kidney disease, 13.2% vs. 15.3%, p=0.73; and maintain dialysis at 90day, 0.0% vs. 0.8%, p=0.482. 결론: In conclusion, intravenous contrast media administration was not associated with long-term mortality, chronic renal impairment, and dialysis in patients with septic AKI. [ABSTRACT FROM AUTHOR]