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AUTOIMMUNE HAEMOLYTIC ANAEMIA INDUCED IN MICE IMMUNIZED WITH RAT ERYTHROCYTES.
- Source :
- Clinical & Experimental Immunology; Jun1974, Vol. 17 Issue 2, p319-327, 9p
- Publication Year :
- 1974
-
Abstract
- C<subscript>3</subscript>H mice immunized with rat erythrocytes developed autoimmune haemolytic anaemia which was very similar to the 'warm-type' autoimmune haemolytic anaemia of man. There was evidence of anaemia, reticulocytosis, shortened survival times of <superscript>51</superscript>Cr-labelled erythrocytes in vivo, and a high incidence of positive direct Coombs' tests. There was no evidence of spherocytosis or of increased susceptibility to osmotically induced lysis. Bone marrow smears showed evidence of erythroid hyperplasia. Splenectomized mice were more severely affected than unsplenectomized mice. In these mice anaemia was more severe, individual positive direct Coombs' tests were stronger: <superscript>51</superscript>Cr-labelled erythrocytes were cleared faster and the compensatory erythroid hyperplasia was less marked. After immunization was stopped both groups of mice quickly became haematologically normal. However, in mice in which immunization was continued, the blood pictures eventually reverted towards normal except for the persistent positive direct Coombs' tests. C57/B1 mice were also susceptible to the disease process but to a much lesser degree than C<subscript>3</subscript>H mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- ERYTHROCYTES
AUTOIMMUNE diseases
IMMUNE system
HYPERPLASIA
BONE marrow
BLOOD cells
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 17
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16244694