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Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases.

Authors :
Wu, Ze
Li, Linghui
Qu, Hui
Qi, Rui-Qun
Niu, Jun
Source :
Journal of Immunology Research; 3/14/2023, p1-10, 10p, 2 Diagrams, 1 Chart, 3 Graphs
Publication Year :
2023

Abstract

Background. Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities. Objective. To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis. Methods. A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model. Results. Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs, P < 0.0001) and pSTAT1 (P = 0.0003) were observed in lesion samples of GA versus sarcoidosis patients. In GA patients, MMP-9 was significantly upregulated in the interstitial type (P = 0.0222), while staining of pSTAT1 was positively correlated with the area of mucinous collagen in palisading GA (R = 0.5356 , P = 0.0484). In sarcoidosis patients, MMP-9 (R = − 0.7127 , P = 0.0009) and pSTAT1 (R = − 0.5604 , P = 0.0067) were found to show stronger expressions in lesions with less lymphocyte infiltration. The predictive model demonstrated an AUC of 0.9675. Conclusion. These results indicate that MMP-9 and pSTAT1 might exert roles in granulomatous inflammation in different modes, and the presence of more robust MMP-9 staining in EFs appears to be more suggestive of GA. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23148861
Database :
Complementary Index
Journal :
Journal of Immunology Research
Publication Type :
Academic Journal
Accession number :
162474314
Full Text :
https://doi.org/10.1155/2023/4098459