Back to Search
Start Over
Early initiation of treatment with oral propranolol for infantile hemangioma improves success rate.
- Source :
- Pediatric Dermatology; Mar/Apr2023, Vol. 40 Issue 2, p261-264, 4p
- Publication Year :
- 2023
-
Abstract
- Background/Objectives: Early referral and treatment of infantile hemangioma (IH) is a major challenge for treatment success. However, there is a lack of data supporting a specific threshold for initiating treatment with oral propranolol. The aim of this analysis was to find factors, such as age at treatment initiation, leading to a higher success rate with oral propranolol treatment. Methods: Based on data from the pivotal phase 2–3 clinical trial of oral propranolol in IH, we used Generalized Additive Model (GAM) charts with Generalized Linear Models (GLM), then a rule discovery algorithm, to identify sub‐groups presenting a high probability of occurrence of the predefined outcome (i.e., success [complete or nearly complete resolution of the target hemangioma] at 6 months of treatment). Results: Our analyses identified that patients who started oral propranolol 3 mg/kg/day before the age of 10 weeks had a success rate of 86%, higher than the 60% success rate for all patients that received the same regimen commencing after 10 weeks of age. Conclusions: Treatment initiation before 10 weeks of age was associated with a significantly higher rate of treatment success with oral propranolol 3 mg/kg/day. Infants with IH requiring treatment should be referred to an expert center and treated as soon as possible. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07368046
- Volume :
- 40
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Pediatric Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 162756956
- Full Text :
- https://doi.org/10.1111/pde.15198