Health-related quality of life in various health conditions: two consecutive surveys of older Japanese adults.

Purpose: Measuring health-related quality of life (HRQOL) in various health conditions in different countries is important given the regional differences. This study employed large-scale nationwide data targeting older adults in Japan to estimate the HRQOL in the key health conditions that are the major causes of disability. Methods: Our data were derived from two survey waves (2016 and 2019 surveys) of cross-sectional data from the Japan Gerontological Evaluation Study, an ongoing nationwide study targeting functionally independent older adults in Japan. A total of 28,345 individuals from 27 of the 47 Japanese provinces were analyzed. The EuroQoL 5-dimension 5-level instrument (EQ-5D-5L) was employed to assess the HRQOL utility scores. The targeted minimum loss-based estimator with sampling weighting methods was applied to estimate the utility score in eight major health conditions, including sensory organ disease, musculoskeletal disease, oral disorders, and depressive disorders. Results: The estimated HRQOL utility score for those with the poorest health conditions in self-rated health, hearing loss, vision loss, number of remaining teeth (e.g., no teeth with no denture use), oral dysfunction, depressive symptoms, chronic low back pain, and chronic knee pain was 0.576 (95% confidence interval (CI) 0.555–0.598), 0.768 (95% CI 0.737–0.800), 0.680 (95% CI 0.662–0.699), 0.809 (95% CI 0.796–0.821), 0.776 (95% CI 0.764–0.788), 0.723 (95% CI 0.710–0.737), 0.715 (95% CI 0.690–0.739), and 0.742 (95% CI 0.722–0.763), respectively. Conclusion: We successfully provided a catalog for the HRQOL utility score in key health conditions that are the leading causes of disability among older adults. [ABSTRACT FROM AUTHOR]