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Copper‐Catalyzed Enantioselective Trifluoromethoxylation of Propargyl Sulfonates.
- Source :
- Angewandte Chemie International Edition; 4/24/2023, Vol. 62 Issue 18, p1-6, 6p
- Publication Year :
- 2023
-
Abstract
- Due to the strong electron‐withdrawing nature and high lipophilicity of trifluoromethoxy group (OCF3), methods for introducing OCF3 into organic molecules are in high demand. However, the research area of direct enantioselective trifluoromethoxylation is still in the embryonic stage, with limited enantioselectivity and/or reaction types. Here, we describe the first copper‐catalyzed enantioselective trifluoromethoxylation of propargyl sulfonates using trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxy source in up to 96 % ee. [ABSTRACT FROM AUTHOR]
- Subjects :
- SULFONATES
SUPPLY & demand
COPPER
LIPOPHILICITY
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 163140345
- Full Text :
- https://doi.org/10.1002/anie.202218919