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The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.

The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.

Authors :
Simpson, Brittany N
Sang, Miguel E Mejía
Puello, Yonairy Collado
Brockmans, Elvira J Diaz
Soto, María F Díaz
Defilló, Stephanie M Rivera
Cruz, Karla M Taveras
Pérez, Javier O Santiago
Husami, Ammar
Day, Melissa E
Pilipenko, Valentina
Mena, Rafael
Mota, Cesár
Hostetter, Margaret K
Muglia, Louis J
Schlaudecker, Elizabeth
Rey, Javier Gonzalez del
Martin, Lisa J
Prada, Carlos E
Source :
Journal of the Pediatric Infectious Diseases Society; Mar2023, Vol. 12 Issue 3, p169-172, 4p
Publication Year :
2023

Abstract

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20487193
Volume :
12
Issue :
3
Database :
Complementary Index
Journal :
Journal of the Pediatric Infectious Diseases Society
Publication Type :
Academic Journal
Accession number :
163171690
Full Text :
https://doi.org/10.1093/jpids/piac136