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Sex- and race-specific associations of bone mineral density with incident heart failure and its subtypes in older adults.
- Source :
- Journal of the American Geriatrics Society; Mar2023, Vol. 71 Issue 3, p742-755, 14p
- Publication Year :
- 2023
-
Abstract
- Background: Previous studies have suggested an association between bone mineral density (BMD) and heart failure (HF) risk that may be racedependent. Methods: We evaluated the relationship between BMD and incident HF in a cohort of older adults, the Health, Aging, and Body Composition (Health ABC) study (n = 2835), and next performed a pooled analysis involving a second older cohort, the Cardiovascular Health Study (n = 1268). Hip BMD was measured by dual-energy X-ray absorptiometry in both cohorts and spine BMD by computed tomography in a subset from Health ABC. Results: In Health ABC, lower BMD at the total hip was associated with higher incident HF in Black women after multivariable adjustment. Similar associations were found for BMD at the femoral neck and spine. In both cohorts, pooled analysis again revealed an association between lower total hip BMD and increased risk of HF in Black women (HR = 1.41 per 0.1-g/cm² decrement [95% CI = 1.23–1.62]), and showed the same to be true for White men (HR = 1.12 [1.03–1.21]). There was a decreased risk of HF in Black men (HR 0.80 [0.70–0.91]), but no relationship in White women. The associations were numerically stronger with HFpEF for Black women and White men, and with HFrEF for Black men. Findings were similar for femoral neck BMD. Sensitivity analyses delaying HF follow-up by 2 years eliminated the association in Black men. Conclusions: Lower BMD was associated with higher risk of HF and especially HFpEF in older Black women and White men, highlighting the need for additional investigation into underlying mechanisms. [ABSTRACT FROM AUTHOR]
- Subjects :
- SPINE physiology
HIP joint physiology
PATIENT aftercare
PHOTON absorptiometry
CONFIDENCE intervals
VENTRICULAR ejection fraction
RACE
FEMUR neck
SEX distribution
RESEARCH funding
BONE density
COMPUTED tomography
WHITE people
SENSITIVITY & specificity (Statistics)
HEART failure
LONGITUDINAL method
AFRICAN Americans
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 71
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 163171830
- Full Text :
- https://doi.org/10.1111/jgs.18121