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Scale-up and Economic Assessment of Biofunctional Particles Synthesis for Bilirubin Removal.
- Source :
- Applied Sciences (2076-3417); Apr2023, Vol. 13 Issue 8, p5150, 17p
- Publication Year :
- 2023
-
Abstract
- The scale-up and the economic feasibility of the synthesis of St-MMA-GMA-PEGMA particles biofunctionalized with HSA were studied. First, the geometrical similarity of laboratory and pilot plant reactors was checked to develop the scale up of the process according to a criterion of partial similarity. The selected criterion was constant Re number. Then, a reaction in the pilot plant scale was carried out, confirming the suitability of the scale-up criterion, since particles with similar characteristics (same particle size with a deviation of just 6%) and functional groups were obtained. Finally, the design of an industrial plant able to produce 581 Tm/year of HSA functionalized St-MMA-GMA-PEGMA particles was addressed. The economic feasibility of this plant was confirmed by a value of internal rate of return (IRR) of 14.8% and a net present value (NPV) of 5452 M€, with a payback time between six and seven years, for the price of a cartridge 25% lower than that from the current treatments for bilirubin removal from patients with liver failure. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERNAL rate of return
BILIRUBIN
NET present value
PILOT plants
FACTORIES
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 13
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Applied Sciences (2076-3417)
- Publication Type :
- Academic Journal
- Accession number :
- 163375823
- Full Text :
- https://doi.org/10.3390/app13085150