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Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones.
- Source :
- EFSA Journal; Apr2023, Vol. 21 Issue 4, p1-16, 16p
- Publication Year :
- 2023
-
Abstract
- The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL‐no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19. For three of these substances [FL‐no: 10.023, 10.030 and 13.012], the concern for genotoxicity has been ruled out in previous revisions of Flavouring Group Evaluation 217 (FGE.217). However, in FGE.217Rev2, a concern for genotoxicity could not be ruled out for 3a,4,5,7a‐tetrahydro‐3,6‐dimethylbenzofuran‐2(3H)‐one [FL‐no: 10.057]. After publication of FGE.217Rev2, industry provided additional genotoxicity studies for [FL‐no: 10.057], which are evaluated in the present opinion FGE.217Rev3. The flavouring substance [FL‐no: 10.057] did not induce gene mutations or numerical or structural chromosomal aberrations in vitro. Based on these data, the Panel concluded that the concern for genotoxicity is ruled out for [FL‐no: 10.057]. Consequently, it can be evaluated through the Procedure. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHEMICAL precursors
LACTONES
CHROMOSOME abnormalities
FOOD additives
KETONES
Subjects
Details
- Language :
- English
- ISSN :
- 18314732
- Volume :
- 21
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- EFSA Journal
- Publication Type :
- Academic Journal
- Accession number :
- 163411531
- Full Text :
- https://doi.org/10.2903/j.efsa.2023.7967