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The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy.
- Source :
- Stem Cell Research & Therapy; 4/28/2023, Vol. 14 Issue 1, p1-20, 20p
- Publication Year :
- 2023
-
Abstract
- Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19 treatment
LUNGS
BIOPOLYMERS
THREE-dimensional modeling
COVID-19
POLYMERS
Subjects
Details
- Language :
- English
- ISSN :
- 17576512
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Stem Cell Research & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 163412595
- Full Text :
- https://doi.org/10.1186/s13287-023-03341-4