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Increased risk of venous thromboembolism in splenectomized patients with sickle cell disease.
- Source :
- British Journal of Haematology; May2023, Vol. 201 Issue 4, p793-796, 4p
- Publication Year :
- 2023
-
Abstract
- Keywords: hyposplenism; pulmonary embolism; Sickle cell disease; splenectomy; venous thromboembolism EN hyposplenism pulmonary embolism Sickle cell disease splenectomy venous thromboembolism 793 796 4 05/05/23 20230515 NES 230515 Sickle cell disease (SCD) is the main cause of functional asplenia, due to splenic atrophy that is generally complete by five years of age in patients with severe genotypes (i.e., homozygous SS and S I i SP 0 sp -thalassaemia).[1] In addition, unpredictable complications, such as acute splenic sequestration (ASS) and hypersplenism, may require surgical splenectomy in up to 30% of patients.[2] Some authors have reported an increase in acute chest syndrome (ACS) and vaso-occlusive crisis (VOC) in the few years following the procedure in children,[3] but data on the long-term consequences of splenectomy in SCD adults are scarce. PATIENT CONSENT STATEMENT We have obtained verbal consent from the patient or patient's parent/guardian. This study showed that SCD patients of S I i SP 0 sp genotype or with an associated -thalassaemia trait were more likely to be splenectomized than SS patients. VTEs included deep vein thrombosis (DVT) and pulmonary embolism (PE) while central venous catheter (CVC)-related thromboses were excluded. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 201
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 163487552
- Full Text :
- https://doi.org/10.1111/bjh.18743