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T cell-derived exosomes in tumor immune modulation and immunotherapy.
- Source :
- Frontiers in Immunology; 2023, p1-8, 8p
- Publication Year :
- 2023
-
Abstract
- Exosomes are nanoscale vesicles secreted by most cells and have a phospholipid bilayer structure. Exosomes contain DNA, small RNA, proteins, and other substances that can carry proteins and nucleic acids and participate in communication between cells. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in the tumor immune response. In this review, we discuss the function of exosomes derived from different T cell subsets, explore applications in tumor immunotherapy, and consider the associated challenges. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOREGULATION
EXOSOMES
T cells
NON-coding RNA
IMMUNOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 163509852
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1130033