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BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination.

Authors :
Zhang, Naijin
Zhang, Ying
Chen, Yong
Qian, Hao
Wu, Boquan
Lu, Saien
You, Shilong
Xu, Wancheng
Zou, Yuanming
Huang, Xinyue
Wang, Wenbin
Liu, Jingwei
Li, Da
Cao, Liu
Sun, Yingxian
Source :
Cell Discovery; 5/8/2023, Vol. 9 Issue 1, p1-5, 5p
Publication Year :
2023

Abstract

S8a, BAF155 overexpression resulted in increased expression of PARP1, whereas BAF155 silencing remarkably downregulated the expression of PARP1 (Supplementary Fig. To identify the potential target of BAF155, cardiac tissues from Ang II-treated I BAF155 i -cWT, I BAF155 i -cKO, I BAF155 i -WT, and I BAF155 i -TG mice were collected for quantitative proteomic analysis (Fig. We further examined the regulation of PARP1 by BAF155 in the established mouse model of Ang II-induced cardiac hypertrophy and fibrosis. [Extracted from the article]

Details

Language :
English
ISSN :
20565968
Volume :
9
Issue :
1
Database :
Complementary Index
Journal :
Cell Discovery
Publication Type :
Academic Journal
Accession number :
163614071
Full Text :
https://doi.org/10.1038/s41421-023-00555-x