BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination.

S8a, BAF155 overexpression resulted in increased expression of PARP1, whereas BAF155 silencing remarkably downregulated the expression of PARP1 (Supplementary Fig. To identify the potential target of BAF155, cardiac tissues from Ang II-treated I BAF155 i -cWT, I BAF155 i -cKO, I BAF155 i -WT, and I BAF155 i -TG mice were collected for quantitative proteomic analysis (Fig. We further examined the regulation of PARP1 by BAF155 in the established mouse model of Ang II-induced cardiac hypertrophy and fibrosis. [Extracted from the article]