ACCUMULATION TIME OF DIFFUSION IN A 3D SINGULARLY PERTURBED DOMAIN.

Boundary value problems for diffusion in singularly perturbed domains is a topic of considerable current interest. Applications include intracellular diffusive transport and the spread of pollutants or heat from localized sources. In a previous paper, we introduced a new method for characterizing the approach to steady state in the case of two-dimensional (2D) diffusion. This was based on a local measure of the relaxation rate known as the accumulation time T(x). The latter was calculated by solving the diffusion equation in Laplace space using a combination of matched asymptotics and Green's function methods. We thus obtained an asymptotic expansion of T(x) in powers of \nu = 1/ln \ε, where \ε specifies the relative size of the holes. In this paper, we develop the corresponding theory for three-dimensional (3D) diffusion. The analysis is a nontrivial extension of the 2D case due to differences in the singular nature of the Laplace transformed Green's function. In particular, the asymptotic expansion of the solution of the 3D diffusion equation in Laplace space involves terms of order O((\epsilon/s)n), where s is the Laplace variable. These s-singularities have to be removed by partial series resummations in order to obtain an asymptotic expansion of T(x) in powers ofε. [ABSTRACT FROM AUTHOR]