Back to Search
Start Over
Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata.
- Source :
- Chemistry of Natural Compounds; Jan2023, Vol. 59 Issue 1, p46-51, 6p
- Publication Year :
- 2023
-
Abstract
- Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga pustulata. The structures of the new compounds 1 and 2 were established by detailed spectroscopic data analysis and ECD computational methods. The inhibitory effects of compounds 1–6 against NLRP3 inflammasome activation as well as the cytotoxic activities of compounds 1–4 against MCF-7 and HCT-116 cancer cell lines were investigated. Compound 3 showed weak cytotoxicity against HCT-116 (IC<subscript>50</subscript> = 55.747 ± 3.212 μM). [ABSTRACT FROM AUTHOR]
- Subjects :
- FLAVONES
NLRP3 protein
INFLAMMASOMES
CELL lines
CANCER cells
FLAVONOIDS
DATA analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 59
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 163886705
- Full Text :
- https://doi.org/10.1007/s10600-023-03914-y