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Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata.

Authors :
Kaunda, Joseph Sakah
Chen, Yuan-Si
Xu, Yao-Jun
Yue, Chen-Fang
Zhang, Xing-Jie
Cheng, Bin
Amin, Muhammad
Li, Hong-Liang
Li, Xiao-Li
Xiao, Wei-Lie
Source :
Chemistry of Natural Compounds; Jan2023, Vol. 59 Issue 1, p46-51, 6p
Publication Year :
2023

Abstract

Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga pustulata. The structures of the new compounds 1 and 2 were established by detailed spectroscopic data analysis and ECD computational methods. The inhibitory effects of compounds 1–6 against NLRP3 inflammasome activation as well as the cytotoxic activities of compounds 1–4 against MCF-7 and HCT-116 cancer cell lines were investigated. Compound 3 showed weak cytotoxicity against HCT-116 (IC<subscript>50</subscript> = 55.747 ± 3.212 μM). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00093130
Volume :
59
Issue :
1
Database :
Complementary Index
Journal :
Chemistry of Natural Compounds
Publication Type :
Academic Journal
Accession number :
163886705
Full Text :
https://doi.org/10.1007/s10600-023-03914-y