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Flavonoids from the fruits of Phyllanthus acidus (L.) Skeels with anti-α-glucosidase activity.
- Source :
- Natural Product Research; Jun2023, Vol. 37 Issue 12, p1986-1992, 7p
- Publication Year :
- 2023
-
Abstract
- Eleven flavonoids including one new flavonol glycoside, quercetin-3-O-(2-α-L-rhamnopyranosyl)-β-D-glucuronopyranosyl methyl ester (1), were isolated for the first time from the fruits of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were determined by extensive spectroscopic data. The known flavonoids, quercetin-3-O-β-D-glucuronide methyl ester (3), quercetin-3-O-(2''-α-L-rhamnopyranosyl-6''-O-α-L-rhamno pyranosyl)-β-D-glucopyranoside (5), myricetin (9), and 6-methoxy-naringenin (11) were isolated for the first time from the genus Phyllanthus. Flavonoids 4, 6 and 9 (IC<subscript>50</subscript> = 6.01, 6.32, and 7.84 μM, respectively) showed stronger α-glucosidase inhibitory activities than the positive control, acarbose (IC<subscript>50</subscript> = 306.45 μM). The fruits of P. acidus might be further developed as an anti-diabetic food supplement. [ABSTRACT FROM AUTHOR]
- Subjects :
- FLAVONOIDS
PHYLLANTHUS
METHYL formate
DIETARY supplements
ACARBOSE
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 37
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 163955300
- Full Text :
- https://doi.org/10.1080/14786419.2022.2116704