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T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 2/22/2005, Vol. 102 Issue 8, p2904-2909, 6p
- Publication Year :
- 2005
-
Abstract
- During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive search for such a function yielded a very limited and specific result. A micrometer- scale receptor clustering integrated the TCR and CD28 signals required for IL-2 secretion in primary 5C.C7 T cells, a low-affinity/avidity TCR system. 5C.C7 TCR signaling itself was not affected. In addition, central TCR accumulation was not required for any T cell effector function tested in three other TCR transgenic models. Central TCR accumulation thus had a specific role in signaling integration in low-affinity T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cell receptors
SYNAPSES
LYMPHOCYTES
CELL membranes
CELLS
IMMUNE system
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 102
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 16395671
- Full Text :
- https://doi.org/10.1073/pnas.0406867102