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Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down.
- Source :
- European Journal of Applied Physiology; Jul2004, Vol. 92 Issue 3, p328-333, 6p
- Publication Year :
- 2004
-
Abstract
- The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- VON Willebrand factor
FIBRINOLYSIS
OXYGEN
TISSUE plasminogen activator
ANALYSIS of variance
HEMATOCRIT
PHYSIOLOGICAL adaptation
ANTIGENS
BLOOD coagulation factors
COMPARATIVE studies
CONVALESCENCE
EXERCISE
EXERCISE tests
MEDICAL cooperation
PHYSICAL fitness
RESEARCH
RUNNING
EVALUATION research
CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 14396319
- Volume :
- 92
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- European Journal of Applied Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 16398496
- Full Text :
- https://doi.org/10.1007/s00421-004-1098-1