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Use of programmed cell death protein 1 (PD-1) inhibitor therapy in HIV-infected patients with advanced cancer: a single-center study from China.
- Source :
- Infectious Agents & Cancer; 5/30/2023, Vol. 18 Issue 1, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: Anti-PD-1 antibodies have been approved for treating several cancer. However, data regarding the safety and efficacy of these agents in HIV-infected patients with cancer is lacking, because these patients are frequently omitted from clinical trials. Objectives: The primary aim of our research is to assess the safety, activity, and long-term outcomes of PD-1 inhibitors in the treatment of HIV-infected patients with advanced cancer. Method: We retrospectively analyzed data from HIV-infected patients with advanced cancers who were treated with PD-1 inhibitors at Shanghai Public Health Clinical Center, Shanghai, China. Results: Fifteen HIV-infected patients (all are men; asian; median age, 44) with cancer who were treated with chemotherapy and/or combined the other oncology treatments [along with combined antiretroviral therapy (cART)] prior to Sintilimab (12 out of 15) or Nivolumab (1 out of 11) or Camrelizumab (2 out of 11) injection were identified. Eight patients responded to treatment (disease control rate 53.3%), with 1 got partial response (PR) and 7 were stable. Most treatment-emergent adverse events (TEAEs) were grade 1 or 2 including anemia, leukopenia, hyperglycemia, granulocytopenia, and thrombocytopenia. Eight patients (53.3%) experienced treatment-related AEs (TRAEs) with grades 3/4including myelosuppression, infection, and neurological disorders. CD4<superscript>+</superscript> T cell count and plasma HIV RNA remained stable throughout the treatment. Conclusions: When used in HIV-infected patients with advanced malignancies, PD-1 inhibitors tend to have favorable efficacy, manageable side effects, and no deteriorated impacts on plasma HIV-RNA and CD4<superscript>+</superscript> T cell count. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of monoclonal antibodies
THERAPEUTIC use of antineoplastic agents
PROGRAMMED cell death 1 receptors
HIV infections
IMMUNE checkpoint inhibitors
CYTOMETRY
RETROSPECTIVE studies
RNA
TUMOR classification
TREATMENT effectiveness
CANCER patients
NIVOLUMAB
DESCRIPTIVE statistics
RESEARCH funding
TUMORS
T cells
PSYCHOLOGY of HIV-positive persons
PATIENT safety
LONG-term health care
IMMUNOTHERAPY
Subjects
Details
- Language :
- English
- ISSN :
- 17509378
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Infectious Agents & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 163987709
- Full Text :
- https://doi.org/10.1186/s13027-023-00512-z