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β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1.
- Source :
- Viruses (1999-4915); May2023, Vol. 15 Issue 5, p1204, 10p
- Publication Year :
- 2023
-
Abstract
- Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by Candida albicans and β-glucan in antiviral innate immunity. It showed that C. albicans and β-glucan promoted the expression of interferon-β (IFN-β) and interleukin-6 (IL-6) in mouse macrophages triggered by viral infection. In addition, β-glucan pretreatment attenuated the pathological damage induced by the virus in mouse lungs and promoted the expression of IFN-β. Mechanistically, β-glucan could promote the phosphorylation and ubiquitination of TANK Binding Kinase 1 (TBK1), a key protein of the innate immune pathway. These results suggest that β-glucan can promote innate antiviral immunity, and this bioactive material may be a potential therapeutic target for antiviral treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- BETA-glucans
NATURAL immunity
IMMUNITY
MYCOSES
BACTERIAL diseases
CANDIDA albicans
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 15
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 163988819
- Full Text :
- https://doi.org/10.3390/v15051204