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Utilization of the Pancreas From Donors With an Extremely High Pancreas Donor Risk Index: Report of the National Registry of Pancreas Transplantation.

Authors :
Keizo Kaku
Yasuhiro Okabe
Shinsuke Kubo
Yu Sato
Takanori Mei
Hiroshi Noguchi
Yoshito Tomimaru
Toshinori Ito
Takashi Kenmochi
Masafumi Nakamura
Source :
Transplant International; 2023, p1-9, 9p
Publication Year :
2023

Abstract

Pancreas transplants from expanded criteria donors are performed widely in Japan because there is a shortage of brain-dead donors. However, the effectiveness of this strategy is unknown. We retrospectively studied 371 pancreas transplants to evaluate the possibility of pancreas transplantation from expanded criteria donors by the Pancreas Donor Risk Index (PDRI). Patients were divided into five groups according to quintiles of PDRI values (Q1-Q5). The 1-year pancreas graft survival rates were 94.5% for Q1, 91.9% for Q2, 90.5%for Q3, 89.3% for Q4, and 79.6% for Q5, and were significantly lower with a lower PDRI (p = 0.04). A multivariate analysis showed that the PDRI, donor hemoglobin A1c values, and pancreas transplantation alone significantly predicted 1-year pancreas graft survival (all p < 0.05). Spline curve analysis showed that the PDRI was incrementally associated with an increased risk of 1-year graft failure. In the group with a PDRI ≥ 2.87, 8/56 patients had graft failures within 1 month, and all were due to graft thrombosis. The PDRI is a prognostic factor related to the 1-year graft survival rate. However, pancreas transplantation from high-PDRI donors shows acceptable results and could be an alternative when the donor pool is insufficient. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09340874
Database :
Complementary Index
Journal :
Transplant International
Publication Type :
Academic Journal
Accession number :
164025395
Full Text :
https://doi.org/10.3389/ti.2023.11132