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Globular glial tauopathy type II.

Authors :
Cullinane, Patrick W.
Sidle, Katie
Bhatia, Kailash P.
Revesz, Tamas
Warner, Thomas T.
Source :
Practical Neurology; Apr2023, Vol. 23 Issue 2, p153-156, 5p
Publication Year :
2023

Abstract

The globular glial tauopathies (GGTs) are a rare group of neurodegenerative diseases with fewer than 90 autopsy-confirmed cases reported in the literature. Although there has been some uncertainty about whether GGT is entirely distinct from progressive supranuclear palsy, a recent study of tau filament structures supports the definition of GGT as a separate neuropathological entity. We present a sporadic case of GGT type II presenting with a progressive corticobasal--primary lateral sclerosis overlap syndrome in a 74-year-old woman. Neuropathological examination identified neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial inclusions. We also discuss the clinical features and molecular pathophysiology of GGT. Increased awareness of this condition could become more important as patients with GGT may be candidates for anti-tau therapies currently undergoing clinical evaluation in patients with other tauopathies. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
TAUOPATHIES
RARE diseases

Details

Language :
English
ISSN :
14747758
Volume :
23
Issue :
2
Database :
Complementary Index
Journal :
Practical Neurology
Publication Type :
Academic Journal
Accession number :
164077161
Full Text :
https://doi.org/10.1136/pn-2022-003549