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Targeting outer membrane protein A (OmpA) – inhibitory effect of 2′-hydroxychalcone derivatives on Acinetobacter baumannii and Candida albicans dual-species biofilm formation.
- Source :
- Biofouling; Mar2023, Vol. 39 Issue 3, p316-326, 11p
- Publication Year :
- 2023
-
Abstract
- Biofilm production facilitates microbial colonization of wounds and catheters. Acinetobacter baumannii produces high levels of biofilm and causes difficult-to-treat nosocomial infections. Candida albicans is another strong biofilm producer which may facilitate A. baumannii adhesion by providing hyphae-mediated OmpA-binding sites. Here we tested the potential of 2′-hydroxychalcones to inhibit dual-species biofilm production of A. baumannii and Candida spp., and further predicted the mechanism of structure-related difference in activity. The results suggest that 2′-hydroxychalcones exhibit potent activity against Candida spp./A. baumannii dual-species biofilm production. Particularly active was trifluoromethyl-substituted derivative (p-CF<subscript>3</subscript>), which decreased C. albicans/A. baumannii biomass produced on vein-indwelling parts of the central venous catheterization set by up to 99%. Further, higher OmpA-binding affinity was also calculated for p-CF<subscript>3</subscript>, which together with demonstrated significant ompA-downregulating activity, suggests that superior antibiofilm activity of this chalcone against the tested dual-species community of A. baumannii is mediated through the OmpA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08927014
- Volume :
- 39
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Biofouling
- Publication Type :
- Academic Journal
- Accession number :
- 164224651
- Full Text :
- https://doi.org/10.1080/08927014.2023.2215693