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Digital spatial profiling of the tumor microenvironment in Hodgkin‐like adult T‐cell leukemia/lymphoma.

Authors :
Takeuchi, M.
Miyoshi, H.
Yamada, K.
Nakashima, K.
Sato, K.
Furuta, T.
Moritsubo, M.
Imamoto, T.
Arakawa, F.
Kouno, K.
Ohshima, K.
Source :
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p264-265, 2p
Publication Year :
2023

Abstract

HRS-like cells widely expressed CD80 and CD86, suggesting that CD28-CD80/CD86 interaction is important in the constitutive activation of HTLV-1 infected CD4 SP + sp T cells in Hodgkin-like ATLL. Here, we performed DSP and immunohistochemistry (IHC) to elucidate the interaction between CD30 SP + sp HRS-like cells and CD4 SP + sp T cells in patients with Hodgkin-like ATLL. B Introduction: b Hodgkin-like adult T-cell leukemia/lymphoma (ATLL) is a rare subtype of ATLL harboring CD30 SP + sp Hodgkin and Reed-Sternberg (HRS)-like cells and small to medium CD4 SP + sp T cells infected with human T-cell lymphotropic virus type I (HTLV-1), which mimics classic Hodgkin lymphoma (CHL) histologically. [Extracted from the article]

Details

Language :
English
ISSN :
02780232
Volume :
41
Database :
Complementary Index
Journal :
Hematological Oncology
Publication Type :
Academic Journal
Accession number :
164230966
Full Text :
https://doi.org/10.1002/hon.3164_177