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Digital spatial profiling of the tumor microenvironment in Hodgkin‐like adult T‐cell leukemia/lymphoma.
- Source :
- Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p264-265, 2p
- Publication Year :
- 2023
-
Abstract
- HRS-like cells widely expressed CD80 and CD86, suggesting that CD28-CD80/CD86 interaction is important in the constitutive activation of HTLV-1 infected CD4 SP + sp T cells in Hodgkin-like ATLL. Here, we performed DSP and immunohistochemistry (IHC) to elucidate the interaction between CD30 SP + sp HRS-like cells and CD4 SP + sp T cells in patients with Hodgkin-like ATLL. B Introduction: b Hodgkin-like adult T-cell leukemia/lymphoma (ATLL) is a rare subtype of ATLL harboring CD30 SP + sp Hodgkin and Reed-Sternberg (HRS)-like cells and small to medium CD4 SP + sp T cells infected with human T-cell lymphotropic virus type I (HTLV-1), which mimics classic Hodgkin lymphoma (CHL) histologically. [Extracted from the article]
- Subjects :
- ADULT T-cell leukemia
TUMOR microenvironment
HTLV-I
Subjects
Details
- Language :
- English
- ISSN :
- 02780232
- Volume :
- 41
- Database :
- Complementary Index
- Journal :
- Hematological Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 164230966
- Full Text :
- https://doi.org/10.1002/hon.3164_177