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Metal‐free para‐C−H Hydroxylation of Aryl‐urea Derivatives.
- Source :
- Asian Journal of Organic Chemistry; Jun2023, Vol. 12 Issue 6, p1-4, 4p
- Publication Year :
- 2023
-
Abstract
- The silica gel promoted straightforward remote para‐C−H hydroxylation of aryl‐urea derivatives under metal‐free mild conditions by using diacetoxyiodobenzene as oxidant has been developed. Replacing the Lewis acids with silica gel effectively improved the tolerance of functional groups and resulted in a wide range of target compounds with various substituents in moderate to excellent yields. Moreover, this transformation has been demonstrated that could more effectively and conveniently synthesize pharmaceutical and biomedical compounds which contain 4‐hydroxyarlyurea skeleton. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDROXYLATION
LEWIS acids
UREA derivatives
FUNCTIONAL groups
SILICA gel
Subjects
Details
- Language :
- English
- ISSN :
- 21935807
- Volume :
- 12
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Asian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 164480827
- Full Text :
- https://doi.org/10.1002/ajoc.202300112