Rapid Construction of Hexahydro‐1H‐pyrrolo[3,2‐c]pyridines with Functionalized 1,3‐Enynes and Imines via Palladium Catalysis.

Presented herein is a palladium catalyzed tandem reaction between 3‐aminoethyl group tethered 1,3‐enynes and imines, proceeding through a cascade vinylogous addition/reductive elimination/protonation/allylic amination and 1,3‐hydrogen transfer sequence. A collection of complex hexahydro‐1H‐pyrrolo[3,2‐c]pyridine architectures were straightforwardly constructed in moderate yields and diastereoselectivity. [ABSTRACT FROM AUTHOR]