Back to Search
Start Over
More of the same? Voxelotor spawns a successor, but on what success does it build?
- Source :
- British Journal of Haematology; Jul2023, Vol. 202 Issue 1, p13-15, 3p
- Publication Year :
- 2023
-
Abstract
- Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin. The departure of a second O SB 2 sb from Hb signals that local oxygen is becoming sparse, and as a result the Hb switches over to a state of lower oxygen affinity, anticipating future demands. Sickle hemoglobin oxygen affinity-shifting strategies have unequal cerebrovascular risks. Keywords: VOXELOTOR; sickle cell; sigmoidal oxygen EN VOXELOTOR sickle cell sigmoidal oxygen 13 15 3 06/27/23 20230701 NES 230701 Voxelotor is designed to impeded the polymerization of sickle haemoglobin. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 202
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 164487448
- Full Text :
- https://doi.org/10.1111/bjh.18785