More of the same? Voxelotor spawns a successor, but on what success does it build?

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin. The departure of a second O SB 2 sb from Hb signals that local oxygen is becoming sparse, and as a result the Hb switches over to a state of lower oxygen affinity, anticipating future demands. Sickle hemoglobin oxygen affinity-shifting strategies have unequal cerebrovascular risks. Keywords: VOXELOTOR; sickle cell; sigmoidal oxygen EN VOXELOTOR sickle cell sigmoidal oxygen 13 15 3 06/27/23 20230701 NES 230701 Voxelotor is designed to impeded the polymerization of sickle haemoglobin. [Extracted from the article]