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Selective IgM deficiency in adults: phenotypically and functionally altered profiles of peripheral blood lymphocytes.
- Source :
- Clinical & Experimental Immunology; Jun1987, Vol. 68 Issue 3, p630-637, 8p
- Publication Year :
- 1987
-
Abstract
- Peripheral blood lymphocytes from four patients with selective IgM deficiency were examined phenotypically and functionally. Although B cell subpopulations determined by surface immunoglobulins were within normal or nearly normal range, T8<superscript>+</superscript> cells were significantly increased and T4/T8 ratios were inverted in three patients. IgM specific hyporesponsiveness in the PWM-driven immunoglobulin production system was observed in all four patients. Ia-like antigen positive T cells were increased in two patients; both had increased Leu2a<superscript>+</superscript> Leu15<superscript>+</superscript> suppressor-effector cells. In addition, Leu3a<superscript>+</superscript>Leu8<superscript>+</superscript> suppressor-inducer cells were increased in one of these two patients. Excessive (either IgM-specific or isotype non-specific) suppressor activity of T cells and IgM specific hyporesponsiveness of non-T cells were observed in these two patients in the recombination plaque assay. Although these results showed the complexity of the pathogenesis of this syndrome, they suggested that suppressor-associated T cells may play a role in some patients with selective IgM deficiency. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULIN M
LYMPHOCYTES
ANTIGENS
T cells
LEUCOCYTES
PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 68
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16457790