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Bittersweet Sugars: How Unusual Glycan Structures May Connect Epithelial-to-Mesenchymal Transition and Multidrug Resistance in Cancer.
- Source :
- Medicines; Jun2023, Vol. 10 Issue 6, p36, 8p
- Publication Year :
- 2023
-
Abstract
- Cancer cells are characterized by metabolic reprogramming, which enables their survival in of-ten inhospitable conditions. A very well-documented example that has gained attraction in re-cent years and is already considered a hallmark of transformed cells is the reprogramming of carbohydrate metabolism. Such a feature, in association with the differential expression of en-zymes involved in the biosynthesis of glycoconjugates, generically known as glycosyltransfer-ases, contributes to the expression of structurally atypical glycans when compared to those ex-pressed in healthy tissues. The latest studies have demonstrated that glycophenotypic alterations are capable of modulating multifactorial events essential for the development and/or progres-sion of the disease. Herein, we will address the importance of glycobiology in modern medi-cine, focusing on the ability of unusual/truncated O-linked glycans to modulate two complex and essential phenomena for cancer progression: the acquisition of the multidrug resistance (MDR) phenotype and the activation of molecular pathways associated with the epithelial–mesenchymal transition (EMT) process, an event deeply linked with cancer metastasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23056320
- Volume :
- 10
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Medicines
- Publication Type :
- Academic Journal
- Accession number :
- 164677220
- Full Text :
- https://doi.org/10.3390/medicines10060036