Back to Search
Start Over
Synthesis of 5‐spirocycle camptothecin using ring‐closing metathesis strategy.
- Source :
- Journal of Heterocyclic Chemistry; Jul2023, Vol. 60 Issue 7, p1132-1137, 6p
- Publication Year :
- 2023
-
Abstract
- Camptothecin (CPT) is an important natural product targeting to Topoisomerase I (Topo I). Despite the high antitumor activity, this compound cannot enter clinical trial owing to its high toxicity and low bio‐availability. In this project, the ring‐closing metathesis (RCM) synthesis strategy was employed to introduce spirocycle functional group in the 5‐position of CPT. Thus, in the catalysis of Grubbs II catalyst, 5,5‐diallylcamptothecin underwent RCM reaction to give 5‐spirocycle CPT compound in 73% yield. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 60
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 164701139
- Full Text :
- https://doi.org/10.1002/jhet.4654