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Induction of remission in diabetes by lowering blood glucose.
- Source :
- Frontiers in Endocrinology; 2023, p1-6, 6p
- Publication Year :
- 2023
-
Abstract
- As diabetes continues to grow as major health problem, there has been great progress in understanding the important role of pancreatic beta-cells in its pathogenesis. Diabetes develops when the normal interplay between insulin secretion and the insulin sensitivity of target tissues is disrupted. With type 2 diabetes (T2D), glucose levels start to rise when beta-cells are unable to meet the demands of insulin resistance. For type 1 diabetes (T1D) glucose levels rise as beta-cells are killed off by autoimmunity. In both cases the increased glucose levels have a toxic effect on beta-cells. This process, called glucose toxicity, has a major inhibitory effect on insulin secretion. This beta-cell dysfunction can be reversed by therapies that reduce glucose levels. Thus, it is becoming increasingly apparent that an opportunity exists to produce a complete or partial remission for T2D, both of which will provide health benefit. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD sugar
DISEASE remission
REMISSION induction
TYPE 1 diabetes
TYPE 2 diabetes
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Database :
- Complementary Index
- Journal :
- Frontiers in Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 164773382
- Full Text :
- https://doi.org/10.3389/fendo.2023.1213954