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The checkpoint for agonist selection precedes conventional selection in human thymus.
- Source :
- Science Immunology; 2017, Vol. 2 Issue 8, p1-11, 11p, 6 Graphs
- Publication Year :
- 2017
-
Abstract
- The thymus plays a central role in self-tolerance, partly by eliminating precursors with a T cell receptor (TCR) that binds strongly to self-antigens. However, the generation of self-agonist–selected lineages also relies on strong TCR signaling. How thymocytes discriminate between these opposite outcomes remains elusive. Here, we identified a human agonist–selected PD-1<superscript>+</superscript> CD8αα<superscript>+</superscript> subset of mature CD8αβ<superscript>+</superscript> T cells that displays an effector phenotype associated with agonist selection. TCR stimulation of immature post–β-selection thymocyte blasts specifically gives rise to this innate subset and fixes early T cell receptor alpha variable (TRAV) and T cell receptor alpha joining (TRAJ) rearrangements in the TCR repertoire. These findings suggest that the checkpoint for agonist selection precedes conventional selection in the human thymus. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 24709468
- Volume :
- 2
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Science Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 164979258
- Full Text :
- https://doi.org/10.1126/sciimmunol.aah4232