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Clinical and immunologic implication of neo-osteogenesis in chronic rhinosinusitis.
- Source :
- Expert Review of Clinical Immunology; Aug2023, Vol. 19 Issue 8, p893-901, 9p
- Publication Year :
- 2023
-
Abstract
- Chronic rhinosinusitis (CRS) is a multifactorial disease characterized by long-term inflammation of the nasal and sinus passages. Neo-osteogenesis which is a major finding of recalcitrant CRS is clinically related to the disease severity and surgical outcomes of CRS. The immunological and molecular mechanisms underlying neo-osteogenesis of CRS remain unclear, and many recent studies have suggested the importance of inflammatory mediators secreted by immune cells. This paper provides a broader understanding of neo-osteogenesis in CRS by reviewing recent updates and evidence of the association between CRS pathophysiology and neo-osteogenesis. Crosstalk between the bone and mucosa eventually results in refractory CRS. In addition, both eosinophilic and non-eosinophilic CRS cytokines can play a role in neo-osteogenesis and trigger an enhanced CRS-associated immune response. The significance of predicting neo-osteogenesis in advance or during postoperative care could be essential for effectively managing refractory CRS and enhancing the prognosis of CRS patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1744666X
- Volume :
- 19
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Expert Review of Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 167363773
- Full Text :
- https://doi.org/10.1080/1744666X.2023.2224962