I2 /DTBP Promoted Synthesis of C3-Carbonylated Imidazopyridines from Chromones and 2-Aminopyridines via (3+2) Cycloaddition.

Keywords: imidazopyridine; cycloaddition; 2-aminopyridine; chromones; DTBP EN imidazopyridine cycloaddition 2-aminopyridine chromones DTBP 2570 2580 11 07/31/23 20230817 NES 230817 Graph Imidazopyridines are an important class of aza-fused heterocycles in the pharmaceutical industry, and they exhibit wide biological activities, Including, anticancer [1] and antibacterial [6] action, central nervous system modulation, [9] and kinase inhibition. HRMS (ESI+): I m i / I z i [M + H] SP + sp calcd for [C SB 14 sb H SB 10 sb BrN SB 2 sb O SB 2 sb ] SP + sp : 316.9920; found: 316.9923. For a proof of concept, we described a novel and facile I SB 2 sb /DTBP promoted synthesis of C3-carbonylated imidazopyridines from chromones and 2-aminopyridines via ring opening (3+2) cycloaddition by employing simple and readily available starting materials. [Extracted from the article]